Microdosing Ketamine

A guide to helping you learn and how to microdose Ketamine as safely as possible.

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How to Dose Ketamine

In formal treatments, ketamine is typically administered in what’s called a ‘sub-anesthetic dose,’ which is not the same as microdosing. According to Ezquerra-Romano, a microdose is defined as any amount below 0.2 milligrams of ketamine per kilogram of body weight. For example, if you weigh 70 kg, you shouldn’t exceed 14 mg per dose. To start, it’s recommended to begin even lower, around 0.1 mg/kg or less, while assessing the effects.

How to Take Ketamine

Once you’ve determined your dose, the most common method for self-administration is intranasally (snorting). While ketamine is often delivered through IV drips or oral tablets in clinical settings, these methods aren’t practical for self-medicating. Although ketamine nasal sprays are available via prescription on the NHS for treatment-resistant depression, they are rare and require a formal diagnosis.

Establish a Protocol

Microdosing psychedelics often involves following a structured schedule or protocol. For substances like psilocybin, this typically involves taking a dose every two to three days, with periodic breaks to prevent tolerance buildup. However, there’s limited research on microdosing ketamine, so Ezquerra-Romano suggests waiting five to seven days between doses to allow your system to reset.

Whether you’re microdosing or using ketamine in larger amounts, maintaining a record of your experience can be beneficial. Consider keeping a microdosing journal or using a notes app to track the dose, its effects, and any aftereffects. Over time, this can help you refine your usage based on your findings.

Potential benefits often associated with ketamine microdosing:

1. Improved Mood and Reduced Depression Symptoms

• Ketamine is known for its rapid antidepressant effects. Even in microdoses, it may help alleviate symptoms of depression by modulating glutamate levels and enhancing neural plasticity.
• Some users report feeling calmer, more positive, and less overwhelmed by negative thoughts.

2. Relief from Anxiety

• Microdosing ketamine might reduce symptoms of anxiety by promoting relaxation and reducing overactivity in stress-related brain pathways.

3. Enhanced Cognitive Flexibility and Creativity

• Ketamine’s effects on the brain’s NMDA receptors may improve creative thinking and problem-solving by encouraging new connections between neurons.
• Users sometimes report increased mental clarity and open-mindedness.

4. Boosted Resilience and Stress Management

• Regular microdosing may help individuals manage stress more effectively, potentially making them more resilient to daily challenges.

5. Treatment of PTSD and Trauma Symptoms

• Microdosing ketamine might help reduce intrusive thoughts, hyperarousal, and other symptoms associated with PTSD, by dampening overactive stress responses and facilitating emotional processing.

6. Improved Focus and Productivity

• Some individuals report enhanced focus and productivity while microdosing ketamine, likely due to its mild stimulating effects at very low doses.

7. Reduced Chronic Pain

• Ketamine’s ability to act as an NMDA receptor antagonist can interrupt pain signaling, making microdoses potentially beneficial for managing chronic pain conditions.

 

Disclaimer:
The information provided here is for educational and informational purposes only and should not be considered medical advice. We are not licensed medical professionals.